# Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer

Source: https://onco.cc/trials/nct06635980/  
OnCo record `nct06635980` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in triple-negative breast cancer, run by Mayo Clinic, now recruiting.

## Summary

Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer is a phase 2, randomised interventional study registered as NCT06635980 by Mayo Clinic, with a registry enrolment figure of 120 participants, started 2025-05-14 and due to reach its primary completion in 2031-10-21. Interventions recorded: Biopsy of Breast; Biospecimen Collection; Breast Surgery; Chemotherapy; Computed Tomography; Contrast Enhanced Digital Mammography; Hypofractionated Radiation Therapy; Magnetic Resonance Imaging; Positron Emission Tomography; Survey Administration; Tissue Collection; Ultrasound Imaging. Conditions listed: Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Breast Carcinoma; Triple-Negative Breast Carcinoma. Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT06635980
- Phase: 2
- Setting: A Randomized Phase II Trial of Hypofractionated Radiotherapy for Non-Metastatic Breast Cancer Before or After Breast Surgery for Different Breast Cancer Risk Groups
- Sponsor: Mayo Clinic
- Enrolled: 120

## Sources

- ClinicalTrials.gov NCT06635980: https://clinicaltrials.gov/study/NCT06635980

## Connected records

- cancers: [Early triple-negative breast cancer](https://onco.cc/cancers/tnbc-early/), [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06635980.json