# Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment

Source: https://onco.cc/trials/nct06642844/  
OnCo record `nct06642844` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by University Hospital, Tours, now recruiting.

## Summary

Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment is a phase 3, randomised interventional study registered as NCT06642844 by University Hospital, Tours, with a registry enrolment figure of 244 participants, started 2025-03-04 and due to reach its primary completion in 2028-03-04. Interventions recorded: Avastin, 25 Mg/mL Intravenous Solution. Conditions listed: Unresectable Metastatic Colorectal Cancer. Primary outcome: The primary endpoint is progression-free survival (PFS). Colorectal eligibility wording from the registry: "* Histologically proven metastatic colorectal adenocarcinoma (on primary tumor and/or metastases) inoperable, well documented, i". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: PHARBEVACOL
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06642844
- Phase: 3
- Setting: Bevacizumab-based Chemotherapy Tailored to the Pharmacokinetics of Bevacizumab in First-line Treatment of Unresectable Metastatic Colorectal Cancer: a Randomized, Multicenter, Double-blind Phase 3 Study
- Sponsor: University Hospital, Tours
- Enrolled: 244

## Sources

- ClinicalTrials.gov NCT06642844: https://clinicaltrials.gov/study/NCT06642844

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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