# Evaluation of Irinotecan Liposome (II) Combined With 5-FU, LV, and Bevacizumab for mCRC

Source: https://onco.cc/trials/nct06643793/  
OnCo record `nct06643793` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of fluorouracil (5-FU), leucovorin (folinic acid) and bevacizumab (glioblastoma use) in colorectal cancer, run by Affiliated Hospital of Nantong University, now recruiting.

## Summary

Evaluation of Irinotecan Liposome (II) Combined With 5-FU, LV, and Bevacizumab for mCRC is a phase 2, interventional study registered as NCT06643793 by Affiliated Hospital of Nantong University, with a registry enrolment figure of 30 participants, started 2024-11-04 and due to reach its primary completion in 2026-10-31. Interventions recorded: Irinotecan liposome (ll) + 5-FU/LV + bevacizumab. Conditions listed: Colorectal Neoplasms Malignant. Primary outcome: Objective response rate (ORR). Colorectal eligibility wording from the registry: "Diagnosis of colorectal cancer by histopathology and/or cytology, clinical Records showing inoperable advanced metastatic colon or rectal cancer (ie, stage IV according to the UICC AJCC TNM staging system \[8th edition 2017\]) ;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06643793
- Phase: 2
- Setting: Evaluation of Irinotecan Liposome (II) Combined With 5-fluorouracil, Leucovorin, and Bevacizumab for Second-line/Third-line Treatment of Metastatic Colorectal Cancer (mCRC): a Prospective and Exploratory Clinical Study
- Sponsor: Affiliated Hospital of Nantong University
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT06643793: https://clinicaltrials.gov/study/NCT06643793

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [Leucovorin (folinic acid)](https://onco.cc/drugs/leucovorin/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct06643793.json