# Neoadjuvant Pembrolizumab With a Watch-and-wait Strategy for dMMR/MSI-H Localized Colon Cancer: PREMICES Study.

Source: https://onco.cc/trials/nct06646445/  
OnCo record `nct06646445` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by GERCOR - Multidisciplinary Oncology Cooperative Group, not yet recruiting.

## Summary

Neoadjuvant Pembrolizumab With a Watch-and-wait Strategy for dMMR/MSI-H Localized Colon Cancer: PREMICES Study. is a phase 2, randomised interventional study registered as NCT06646445 by GERCOR - Multidisciplinary Oncology Cooperative Group, with a registry enrolment figure of 60 participants, started 2025-09 and due to reach its primary completion in 2027-12. Interventions recorded: Pembrolizumab Injection [Keytruda]; Watch-and-wait approach; Surgery; Adjuvant chemotherapy. Conditions listed: Colon Cancer. Primary outcome: The rate of success of the experimental strategy at 6 months or after two successive colonoscopies (corresponding to timepoint at 6 months from the experimental strategy) following randomization.. Colorectal eligibility wording from the registry: "Newly diagnosed, histologically confirmed colonic or upper third rectal adenocarcinoma, NB: material must be available from biopsy done during colonoscopy". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: PREMICES
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06646445
- Phase: 2
- Setting: Neoadjuvant Pembrolizumab With a Watch-and-wait Strategy for Patients With Mismatch Repair-deficient or Microsatellite Instability-high (dMMR/MSI-H) Localized Colon Cancer: a Randomized GERCOR G-109 PRODIGE 84 PREMICES Phase II Trial
- Sponsor: GERCOR - Multidisciplinary Oncology Cooperative Group
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT06646445: https://clinicaltrials.gov/study/NCT06646445

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- companies: [GERCOR](https://onco.cc/companies/gercor/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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