# CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized CRC

Source: https://onco.cc/trials/nct06652412/  
OnCo record `nct06652412` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of sintilimab, fluorouracil (5-FU), raltitrexed, fOLFOX (5-FU, leucovorin, oxaliplatin) and other drugs in colorectal cancer, run by Fudan University, not yet recruiting.

## Summary

CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized CRC is a phase 2, interventional study registered as NCT06652412 by Fudan University, with a registry enrolment figure of 124 participants, started 2024-11 and due to reach its primary completion in 2027-11. Interventions recorded: Ultrafractionated RT and CGA Guided systemic treatment.; data prospectively collected; Ultrafractionated Radiotherapy; Sintilimab; Fluorouracil; Raltitrexed; Oxaliplatin; Irinotecan (CPT-11). Conditions listed: Colon Cancer; Rectal Cancer. Primary outcome: Complete response (CR) rate. Colorectal eligibility wording from the registry: "Pathologically confirmed Colorectal adenocarcinoma;". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06652412
- Phase: 2
- Setting: Comprehensive Geriatric Assessment (CGA) Guided Ultrafractionated Radiotherapy and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized Colorectal Cancer
- Sponsor: Fudan University
- Enrolled: 124

## Sources

- ClinicalTrials.gov NCT06652412: https://clinicaltrials.gov/study/NCT06652412

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Raltitrexed](https://onco.cc/drugs/raltitrexed/), [Sintilimab](https://onco.cc/drugs/sintilimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06652412.json