# A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Source: https://onco.cc/trials/nct06667076/  
OnCo record `nct06667076` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Amivantamab, Lazertinib, Pemetrexed and Carboplatin in non-small-cell lung cancer, run by Janssen Research & Development, LLC, now recruiting.

## Summary

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) is a phase 2 interventional study registered as NCT06667076 by Janssen Research & Development, LLC, with 480 participants planned, started 2024-12-16 and due to reach its primary completion in 2029-05-23. Interventions recorded: Amivantamab, Lazertinib, Chemotherapy: Pemetrexed and Chemotherapy: Carboplatin.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: pipeline; ctgov-ingest
- Registry id: NCT06667076
- Phase: 2
- Setting: A Phase 2b, Open-Label, Two-cohort Study of Subcutaneous Amivantamab in Combination With Lazertinib as First-Line Treatment, or Subcutaneous Amivantamab in Combination With Platinum-Based Chemotherapy as Second-line Treatment, for Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
- Sponsor: Janssen Research & Development, LLC
- Enrolled: 480

## Sources

- ClinicalTrials.gov NCT06667076: https://clinicaltrials.gov/study/NCT06667076

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [Amivantamab](https://onco.cc/drugs/amivantamab/), [Carboplatin](https://onco.cc/drugs/carboplatin/), [Lazertinib](https://onco.cc/drugs/lazertinib/), [Pemetrexed](https://onco.cc/drugs/pemetrexed/)
- companies: [Johnson & Johnson](https://onco.cc/companies/johnson-johnson/)

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