# NALIRIFOX Combined With PD-1 Sequential Radiotherapy Versus NALIRIFOX as Conversion Therapy of Locally Advanced Pancreatic Cancer

Source: https://onco.cc/trials/nct06669078/  
OnCo record `nct06669078` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of fluorouracil (5-FU) in pancreatic cancer, run by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, not yet recruiting.

## Summary

NALIRIFOX Combined With PD-1 Sequential Radiotherapy Versus NALIRIFOX as Conversion Therapy of Locally Advanced Pancreatic Cancer is a phase 2, randomised interventional study registered as NCT06669078 by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, with a registry enrolment figure of 120 participants, started 2024-10-30 and due to reach its primary completion in 2027-10-15. Interventions recorded: Nal-lRl+Oxaliplain+5- FU +PD 1; Nal-lRl+Oxaliplain+5- FU. Conditions listed: Locally Advanced Pancreatic Cancer. Primary outcome: 1 year OS rate. Pancreatic eligibility wording from the registry: "Histologically or cytologically confi rmed pancreatic cancer;". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: NALIRIFOX
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06669078
- Phase: 2
- Setting: A Prospective, Open, Randomized Controlled, Multicenter, Exploratory Clinical Study of NALIRIFOX Combined With PD-1 Sequential Radiotherapy Versus NALIRIFOX for Conversion Therapy for Locally Advanced Pancreatic Cancer
- Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
- Enrolled: 120

## Sources

- ClinicalTrials.gov NCT06669078: https://clinicaltrials.gov/study/NCT06669078

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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