# Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

Source: https://onco.cc/trials/nct06686771/  
OnCo record `nct06686771` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by Canadian Cancer Trials Group, now recruiting.

## Summary

Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT06686771 by Canadian Cancer Trials Group, with a registry enrolment figure of 320 participants, started 2025-12-16 and due to reach its primary completion in 2030-02-28. Interventions recorded: SBRT; First or second-line standard of care therapy. Conditions listed: Non-small Cell Lung Cancer. Primary outcome: Progression-free survival; Overall survival. Lung eligibility wording from the registry: "* Metastatic disease (stage IV) detected on imaging and histologically and/or cytologically confirmed NSCLC as per the WHO Classification of Tumors and AJCC 8th Edition TNM Classification, without a driver mutation with an actionable first-line targeted therapy, for whom either ICI alone or combinat". Sites: Canada, United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: CURB2
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06686771
- Phase: 3
- Setting: Consolidative Use of Radiotherapy to Block (CURB2) Oligoprogression In Patients With Metastatic Non-Small-Cell Lung Cancer
- Sponsor: Canadian Cancer Trials Group
- Enrolled: 320

## Sources

- ClinicalTrials.gov NCT06686771: https://clinicaltrials.gov/study/NCT06686771

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- companies: [Canadian Cancer Trials Group (CCTG)](https://onco.cc/companies/cctg/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct06686771.json