# Efficacy and Safety of First-line Treatment for Extensive-stage Small Cell Lung Cancer Using a Combination Therapy of Trilaciclib, Envafolimab, Etoposide, and C

Source: https://onco.cc/trials/nct06698965/  
OnCo record `nct06698965` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of carboplatin and trilaciclib in lung cancer, run by Shanghai Chest Hospital, now recruiting.

## Summary

Efficacy and Safety of First-line Treatment for Extensive-stage Small Cell Lung Cancer Using a Combination Therapy of Trilaciclib, Envafolimab, Etoposide, and Carboplatin is a phase 2, randomised interventional study registered as NCT06698965 by Shanghai Chest Hospital, with a registry enrolment figure of 52 participants, started 2024-10-13 and due to reach its primary completion in 2029-10-31. Interventions recorded: Chemotherapy （Etoposide and Carboplatin）; Immunotherapy （Envafolimab）; Trilaciclib. Conditions listed: Lung Cancer, Small Cell. Primary outcome: The incidence of grade ≥ 3 neutropenia during chemotherapy treatment. Lung eligibility wording from the registry: "* Small cell lung cancer (SCLC) confirmed by histology or cytology;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06698965
- Phase: 2
- Setting: A Randomized, Controlled Phase II Clinical Study on the Efficacy and Safety of First-line Treatment for Extensive-stage Small Cell Lung Cancer Using a Combination Therapy of Trilaciclib, Envafolimab, Etoposide, and Carboplatin
- Sponsor: Shanghai Chest Hospital
- Enrolled: 52

## Sources

- ClinicalTrials.gov NCT06698965: https://clinicaltrials.gov/study/NCT06698965

## Connected records

- cancers: [Extensive-stage small-cell lung cancer](https://onco.cc/cancers/extensive-stage-sclc/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Trilaciclib](https://onco.cc/drugs/trilaciclib/)
- companies: [Simcere Pharmaceutical](https://onco.cc/companies/simcere/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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