# A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of 

Source: https://onco.cc/trials/nct06699212/  
OnCo record `nct06699212` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Cetuximab sarotalocan, Pembrolizumab, Carboplatin in head and neck squamous cell carcinoma, run by Rakuten Medical, Inc., now recruiting.

## Summary

A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases is a phase 3 interventional study registered as NCT06699212 by Rakuten Medical, Inc., with 412 participants planned, started 2024-12-24 and due to reach its primary completion in 2028-09. Interventions recorded: ASP-1929 Photoimmunotherapy, Pembrolizumab, Carboplatin, Cisplatin, 5-fluorouracil. Conditions listed: Recurrent Head and Neck Squamous Cell Carcinoma. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT06699212
- Phase: 3
- Setting: A Phase 3 Multicenter, Randomized, Open-label Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab Versus Standard of Care in the First-line Treatment of Patients With Locoregional Recurrence of Squamous Cell Carcinoma of the Head and Neck (HNSCC) With No Distant Metastases
- Sponsor: Rakuten Medical, Inc.
- Enrolled: 412

## Sources

- ClinicalTrials.gov NCT06699212: https://clinicaltrials.gov/study/NCT06699212

## Connected records

- cancers: [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cetuximab sarotalocan](https://onco.cc/drugs/cetuximab-sarotalocan/), [Cisplatin](https://onco.cc/drugs/cisplatin/), [Docetaxel](https://onco.cc/drugs/docetaxel/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)
- companies: [Rakuten Medical](https://onco.cc/companies/rakuten-medical/)

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