# Neoadjuvant Short-Course Radiotherapy With or Without Chemotherapy and AK112 in Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct06718543/  
OnCo record `nct06718543` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of ivonescimab and cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by fan li, now recruiting.

## Summary

Neoadjuvant Short-Course Radiotherapy With or Without Chemotherapy and AK112 in Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT06718543 by fan li, with a registry enrolment figure of 100 participants, started 2025-02-10 and due to reach its primary completion in 2026-10-31. Interventions recorded: AK112 with SCRT and CapeOX; AK112 with SCRT. Conditions listed: Rectal Cancer. Primary outcome: Complete Response Rate. Colorectal eligibility wording from the registry: "Histologically confirmed rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: TRIUNITE-03
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06718543
- Phase: 2
- Setting: A Multicenter, Randomized, Parallel, Non-Controlled, Prospective Phase II Study of Neoadjuvant Short-Course Radiotherapy Sequential With AK112 With or Without Chemotherapy for Locally Advanced Rectal Cancer
- Sponsor: fan li
- Enrolled: 100

## Sources

- ClinicalTrials.gov NCT06718543: https://clinicaltrials.gov/study/NCT06718543

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [Ivonescimab](https://onco.cc/drugs/ivonescimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06718543.json