# Preoperative Chemoradiotherapy and Toripalimab in Locally Recurrent Rectal Cancer

Source: https://onco.cc/trials/nct06751394/  
OnCo record `nct06751394` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of capecitabine, fOLFOX (5-FU, leucovorin, oxaliplatin) and fOLFIRI (5-FU, leucovorin, irinotecan) in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, not yet recruiting.

## Summary

Preoperative Chemoradiotherapy and Toripalimab in Locally Recurrent Rectal Cancer is a phase 2, interventional study registered as NCT06751394 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 44 participants, started 2025-01-01 and due to reach its primary completion in 2028-12-31. Interventions recorded: PD-1 antibody (Toripalimab); Capecitabine; Oxaliplatin; Irinotecan; Radiation; surgery. Conditions listed: Recurrent Rectal Cancer. Primary outcome: Pathological complete response rate. Colorectal eligibility wording from the registry: "Active inflammatory bowel disease or other colorectal diseases that lead to chronic diarrhea". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: TRACER
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06751394
- Phase: 2
- Setting: Preoperative Treatment with Radiotherapy and Anti-PD1 for Resectable Recurrent Rectal Cancer (TRACER)
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 44

## Sources

- ClinicalTrials.gov NCT06751394: https://clinicaltrials.gov/study/NCT06751394

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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