# Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.

Source: https://onco.cc/trials/nct06758830/  
OnCo record `nct06758830` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in colorectal cancer, run by National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos, now recruiting.

## Summary

Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer. is a phase 2/3, randomised interventional study registered as NCT06758830 by National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos, with a registry enrolment figure of 400 participants, started 2025-01-06 and due to reach its primary completion in 2029-12-27. Interventions recorded: Radiation Therapy; Chemoradiotherapy; Consolidation Chemotherapy; Surgery; Part two; Adjuvant treatment. Conditions listed: Rectal Cancer; Total Neoadjuvant Treatment; Neoadjuvant Therapy; Radiotherapy; Chemotherapy; Organ Preservation; Radiotherapy Side Effect; Chemotherapy Side Effects; Chemoradiotherapy; Low Anterior Resection Syndrome; Quality of Life. Primary outcome: Postoperative complications; TNT toxicity; Mortality rate. Colorectal eligibility wording from the registry: "* Pathologically confirmed rectal adenocarcinoma". Sites: Lithuania. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06758830
- Phase: 2/3
- Setting: Total Neoadjuvant Therapy for Rectal Cancer - a New Standard of Care?
- Sponsor: National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
- Enrolled: 400

## Sources

- ClinicalTrials.gov NCT06758830: https://clinicaltrials.gov/study/NCT06758830

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06758830.json