# Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT)

Source: https://onco.cc/trials/nct06770270/  
OnCo record `nct06770270` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of pucotenlimab in colorectal cancer, run by Second Affiliated Hospital, Zhejiang University, School of Medicine, now recruiting.

## Summary

Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT) is a phase 2, interventional study registered as NCT06770270 by Second Affiliated Hospital, Zhejiang University, School of Medicine, with a registry enrolment figure of 68 participants, started 2024-08-01 and due to reach its primary completion in 2027-12-31. Interventions recorded: Pucotenlimab. Conditions listed: Rectal Cancer. Primary outcome: The rate of cCR; The rate of pCR. Colorectal eligibility wording from the registry: "Histologically confirmed and evaluated as locally advanced rectal adenocarcinoma (confirmed by MRI): cT3 or higher; or cN+;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: PUCRT
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06770270
- Phase: 2
- Setting: Pucotenlimab Combined With Radiotherapy and Chemotherapy as Neoadjuvant Therapy for Locally Advanced Rectal Cancer: A Single-Arm Clinical Study(PUCRT)
- Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine
- Enrolled: 68

## Sources

- ClinicalTrials.gov NCT06770270: https://clinicaltrials.gov/study/NCT06770270

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Pucotenlimab](https://onco.cc/drugs/pucotenlimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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