# FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

Source: https://onco.cc/trials/nct06780787/  
OnCo record `nct06780787` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of balstilimab, botensilimab, capecitabine, fluorouracil (5-FU) and other drugs in colorectal cancer, run by City of Hope Medical Center, now recruiting.

## Summary

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery is a phase 2, interventional study registered as NCT06780787 by City of Hope Medical Center, with a registry enrolment figure of 26 participants, started 2025-05-20 and due to reach its primary completion in 2027-11-05. Interventions recorded: Balstilimab; Biospecimen Collection; Botensilimab; Capecitabine; Computed Tomography; Digital Rectal Examination; Endoscopic Biopsy; Fluorouracil; Leucovorin Calcium; Magnetic Resonance Imaging; Oxaliplatin; Radiation Therapy; Sigmoidoscopy. Conditions listed: Rectal Adenocarcinoma; Stage IIA Rectal Cancer AJCC v8; Stage III Rectal Cancer AJCC v8. Primary outcome: Complete clinical response (cCR) rate. Colorectal eligibility wording from the registry: "* Histologically confirmed adenocarcinoma of the rectum". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06780787
- Phase: 2
- Setting: Phase II Clinical Trial of FOLFOX, Botensilimab, Plus Balstilimab in Patients With Localized Rectal Cancer
- Sponsor: City of Hope Medical Center
- Enrolled: 26

## Sources

- ClinicalTrials.gov NCT06780787: https://clinicaltrials.gov/study/NCT06780787

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Balstilimab](https://onco.cc/drugs/balstilimab/), [Botensilimab](https://onco.cc/drugs/botensilimab/), [Capecitabine](https://onco.cc/drugs/capecitabine/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Leucovorin (folinic acid)](https://onco.cc/drugs/leucovorin/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06780787.json