# Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Dif

Source: https://onco.cc/trials/nct06782412/  
OnCo record `nct06782412` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in pancreatic cancer, run by KU Leuven, now recruiting.

## Summary

Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Different Tumor Types is a phase 2/3, interventional study registered as NCT06782412 by KU Leuven, with a registry enrolment figure of 109 participants, started 2025-02-06 and due to reach its primary completion in 2027-12. Interventions recorded: [18F]AlF-FAPI-74 PET/CT. Conditions listed: Oesophageal Cancer; Gastric Cancer; Pancreatic Ductal Adenocarcinoma; FAP; Oncology; Oncologic Disorders. Primary outcome: Primary Objective OGA: demonstrate superiority of [18F]AlF-FAPI-74 PET/CT over [18F]FDG PET/CT.; Primary Objective PDAC: demonstrate superiority of [18F]AlF-FAPI-74 PET/CT over conventional imaging (CT or MRI) or [18F]FDG PET/CT (if available); Primary Objective Clinically Challenging Situation: dem. Pancreatic eligibility wording from the registry: "New histologic or cytologic proven diagnosis of pancreatic ductal adenocarcinoma". Sites: Belgium. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: FAPIDO
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06782412
- Phase: 2/3
- Setting: Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Different Tumor Types
- Sponsor: KU Leuven
- Enrolled: 109

## Sources

- ClinicalTrials.gov NCT06782412: https://clinicaltrials.gov/study/NCT06782412

## Connected records

- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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