# Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon Cancer

Source: https://onco.cc/trials/nct06783491/  
OnCo record `nct06783491` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of mitomycin C and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Maimónides Biomedical Research Institute of Córdoba, now recruiting.

## Summary

Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon Cancer is a phase 3, randomised interventional study registered as NCT06783491 by Maimónides Biomedical Research Institute of Córdoba, with a registry enrolment figure of 1083 participants, started 2026-05-26 and due to reach its primary completion in 2030-06-01. Interventions recorded: Mitomycin (MM); FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin); Cytoreductive surgery. Conditions listed: Locally Advanced Colorectal Cancer. Primary outcome: Disease-free survival absolute; Disease-free survival probability. Colorectal eligibility wording from the registry: "* Adenocarcinoma of the colon, sigmoid colon and rectum-sigmoid junction that is cT4a/b according to the American Joint Committee on Cancer (AJCC) TNM eight edition". Sites: Spain. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: FOXHIPECT4
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06783491
- Phase: 3
- Setting: Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon Cancer: A Phase III Multi-arm, Randomized and Controlled Clinical Trial (FOXHIPECT4)
- Sponsor: Maimónides Biomedical Research Institute of Córdoba
- Enrolled: 1083

## Sources

- ClinicalTrials.gov NCT06783491: https://clinicaltrials.gov/study/NCT06783491

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [HIPEC / PIPAC (intraperitoneal chemotherapy)](https://onco.cc/technologies/hipec/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Mitomycin C](https://onco.cc/drugs/mitomycin/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct06783491.json