# Neoadjuvant CAPOX Plus Ivonescimab Versus CAPOX for Locally Advanced Colon Cancer

Source: https://onco.cc/trials/nct06790212/  
OnCo record `nct06790212` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of ivonescimab, fOLFOX (5-FU, leucovorin, oxaliplatin) and capecitabine in colorectal cancer, run by Sun Yat-sen University, not yet recruiting.

## Summary

Neoadjuvant CAPOX Plus Ivonescimab Versus CAPOX for Locally Advanced Colon Cancer is a phase 2, randomised interventional study registered as NCT06790212 by Sun Yat-sen University, with a registry enrolment figure of 168 participants, started 2025-04-28 and due to reach its primary completion in 2027-08-30. Interventions recorded: Ivonescimab; Oxaliplatin; Capecitabine. Conditions listed: Colon Cancer. Primary outcome: MPR rate. Colorectal eligibility wording from the registry: "Histologically confirmed locally advanced resectable colon adenocarcinoma (colon cancer located more than 12 cm from the anal verge);". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06790212
- Phase: 2
- Setting: A Prospective, Randomized Phase II Study Evaluating CAPOX Combined with Ivonescimab (a PD-1/VEGF-A Bispecific Antibody) Versus CAPOX Alone As Neoadjuvant Therapy in Patients with Locally Advanced Colon Cancer.
- Sponsor: Sun Yat-sen University
- Enrolled: 168

## Sources

- ClinicalTrials.gov NCT06790212: https://clinicaltrials.gov/study/NCT06790212

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Ivonescimab](https://onco.cc/drugs/ivonescimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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