# Posaconazole Plus PD-1 Inhibitors and Chemotherapy vs PD-1 Inhibitors and Chemotherapy in Neoadjuvant Therapy for Triple Negative Breast Cancer

Source: https://onco.cc/trials/nct06802757/  
OnCo record `nct06802757` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of nab-paclitaxel, carboplatin and cyclophosphamide in triple-negative breast cancer, run by Shandong Cancer Hospital and Institute, now recruiting.

## Summary

Posaconazole Plus PD-1 Inhibitors and Chemotherapy vs PD-1 Inhibitors and Chemotherapy in Neoadjuvant Therapy for Triple Negative Breast Cancer is a phase 2, randomised interventional study registered as NCT06802757 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 72 participants, started 2025-05-01 and due to reach its primary completion in 2026-06-30. Interventions recorded: Posaconazole; Nab-paclitaxel; Carboplatin; Anthracycline; Cyclophosphamide; PD-1 inhibitors. Conditions listed: Breast Cancer. Triple-negative eligibility wording from the registry: "first-confirmed TNBC;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: PRISM-TNBC
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT06802757
- Phase: 2
- Setting: A Phase II, Randomised, Open-label, Multicentre Study of Posaconazole Plus PD-1 Inhibitors and Chemotherapy Versus PD-1 Inhibitors and Chemotherapy as Neoadjuvant Therapy for Triple Negative Breast Cancer
- Sponsor: Shandong Cancer Hospital and Institute
- Enrolled: 72

## Sources

- ClinicalTrials.gov NCT06802757: https://clinicaltrials.gov/study/NCT06802757

## Connected records

- cancers: [Early triple-negative breast cancer](https://onco.cc/cancers/tnbc-early/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Nab-paclitaxel](https://onco.cc/drugs/nab-paclitaxel/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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