# Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Patients

Source: https://onco.cc/trials/nct06812728/  
OnCo record `nct06812728` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of fOLFIRINOX / mFOLFIRINOX and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Menoufia University, now recruiting.

## Summary

Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Patients is a phase 2, randomised interventional study registered as NCT06812728 by Menoufia University, with a registry enrolment figure of 100 participants, started 2025-01-25 and due to reach its primary completion in 2027-01-25. Interventions recorded: mFOLFIRINOX; mFolfox6. Conditions listed: Rectum Cancer. Primary outcome: Complete clinical response rate. Colorectal eligibility wording from the registry: "Histologically proven rectal adenocarcinoma". Sites: Egypt. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06812728
- Phase: 2
- Setting: Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy Versus Standard Total Neoadjuvant Approach for Locally Advanced Rectal Cancer Patients: a Randomized Controlled Phase 2 Trial.
- Sponsor: Menoufia University
- Enrolled: 100

## Sources

- ClinicalTrials.gov NCT06812728: https://clinicaltrials.gov/study/NCT06812728

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [FOLFIRINOX / mFOLFIRINOX](https://onco.cc/drugs/folfirinox/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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