# Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC):

Source: https://onco.cc/trials/nct06832917/  
OnCo record `nct06832917` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Wan He, not yet recruiting.

## Summary

Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III) is a phase 3, randomised interventional study registered as NCT06832917 by Wan He, with a registry enrolment figure of 238 participants, started 2025-03-31 and due to reach its primary completion in 2028-12-31. Interventions recorded: AK104 plus; Chemo only. Conditions listed: Rectal Cancer. Primary outcome: 3-year disease free survival (3-y DFS). Colorectal eligibility wording from the registry: "Histopathology confirmed the diagnosis of rectal adenocarcinoma". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: NeoCaCRT-III
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06832917
- Phase: 3
- Setting: A Prospective Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Study to Explore the Efficacy and Safety of Cadonilimab Plus Chemotherapy After Short-course Radiotherapy in Locally Advanced Rectal Cancer
- Sponsor: Wan He
- Enrolled: 238

## Sources

- ClinicalTrials.gov NCT06832917: https://clinicaltrials.gov/study/NCT06832917

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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