# Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR ) Combined With Anti-PD1，Chemotherapy and Target Therapy for Metastatic Colorectal Can

Source: https://onco.cc/trials/nct06841159/  
OnCo record `nct06841159` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of sintilimab in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR ) Combined With Anti-PD1，Chemotherapy and Target Therapy for Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT06841159 by Fudan University, with a registry enrolment figure of 116 participants, started 2024-03-01 and due to reach its primary completion in 2026-03-01. Interventions recorded: Ultra-fractionated radiation therapy; Sintilimab; Standard systemic therapy. Conditions listed: Microsatellite Stable Metastatic Colorectal Cancer. Primary outcome: Progression-Free Survival (PFS). Colorectal eligibility wording from the registry: "* Histopathological confirmed MSS/pMMR adenocarcinoma of the colon or rectum". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: iPULSAR-CRC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06841159
- Phase: 2
- Setting: Phase 2 Study of Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR ) Combined With Anti-PD1, Chemotherapy and Target Therapy for Metastatic Colorectal Cancer(iPULSAR-CRC)
- Sponsor: Fudan University
- Enrolled: 116

## Sources

- ClinicalTrials.gov NCT06841159: https://clinicaltrials.gov/study/NCT06841159

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- drugs: [Sintilimab](https://onco.cc/drugs/sintilimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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