# A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma

Source: https://onco.cc/trials/nct06843434/  
OnCo record `nct06843434` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of balstilimab and botensilimab in colorectal cancer, run by Memorial Sloan Kettering Cancer Center, now recruiting.

## Summary

A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma is a phase 2, interventional study registered as NCT06843434 by Memorial Sloan Kettering Cancer Center, with a registry enrolment figure of 40 participants, started 2025-02-20 and due to reach its primary completion in 2028-02-20. Interventions recorded: Balstilimab; Botensilimab. Conditions listed: Microsatellite Stable Rectal Carcinoma; Locally Advanced Rectal Adenocarcinoma. Primary outcome: Best Overall Response Rate. Colorectal eligibility wording from the registry: "* Histologically confirmed rectal adenocarcinoma". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06843434
- Phase: 2
- Setting: A Phase II Study of Neoadjuvant Botensilimab and Balstilimab Immunotherapy for Mismatch Repair Proficient Rectal Adenocarcinoma
- Sponsor: Memorial Sloan Kettering Cancer Center
- Enrolled: 40

## Sources

- ClinicalTrials.gov NCT06843434: https://clinicaltrials.gov/study/NCT06843434

## Connected records

- cancers: [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Balstilimab](https://onco.cc/drugs/balstilimab/), [Botensilimab](https://onco.cc/drugs/botensilimab/)
- companies: [Agenus](https://onco.cc/companies/agenus/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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