# The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation

Source: https://onco.cc/trials/nct06843551/  
OnCo record `nct06843551` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of botensilimab and balstilimab in pancreatic cancer, run by Benjamin Spieler, now recruiting.

## Summary

The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation is a phase 2, interventional study registered as NCT06843551 by Benjamin Spieler, with a registry enrolment figure of 20 participants, started 2025-06-18 and due to reach its primary completion in 2030-08-01. Interventions recorded: Stereotactic Body Radiation Therapy; Botensilimab; Balstilimab. Conditions listed: Metastatic Pancreatic Ductal Adenocarcinoma; Metastatic Pancreatic Cancer. Primary outcome: Clinical Benefit Rate (CBR). Pancreatic eligibility wording from the registry: "Histologically or cytologically confirmed diagnosis of pancreatic ductal adenocarcinoma". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: EMPIRE
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06843551
- Phase: 2
- Setting: A Phase 2 Single Arm Trial of Stereotactic Body Radiation Therapy Followed by Dual Immune Checkpoint Inhibition for Patients With Metastatic Pancreatic Ductal Adenocarcinoma - The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation
- Sponsor: Benjamin Spieler
- Enrolled: 20

## Sources

- ClinicalTrials.gov NCT06843551: https://clinicaltrials.gov/study/NCT06843551

## Connected records

- cancers: [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- drugs: [Balstilimab](https://onco.cc/drugs/balstilimab/), [Botensilimab](https://onco.cc/drugs/botensilimab/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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