# Adapted Guided Stereotactic Body Radiotherapy Combined With Chemotherapy and Enhancement of Novel Drug Ivonescimab for Pancreatic Cancer (ASCEND)

Source: https://onco.cc/trials/nct06844422/  
OnCo record `nct06844422` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of ivonescimab in pancreatic cancer, run by Shandong Cancer Hospital and Institute, now recruiting.

## Summary

Adapted Guided Stereotactic Body Radiotherapy Combined With Chemotherapy and Enhancement of Novel Drug Ivonescimab for Pancreatic Cancer (ASCEND) is a phase 1/2, interventional study registered as NCT06844422 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 37 participants, started 2025-02-08 and due to reach its primary completion in 2028-02-18. Interventions recorded: Ivonescimab. Conditions listed: Pancreatic Cancer. Primary outcome: Maximum Tolerated Dose (MTD); Dose-Limiting Toxicity (DLT); Recommended Phase 2 Dose (RP2D). Pancreatic eligibility wording from the registry: "At least one measurable pancreatic cancer lesion, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06844422
- Phase: 1/2
- Setting: Adapted Guided Stereotactic Body Radiotherapy Combined With Chemotherapy and Enhancement of Novel Drug Ivonescimab for Pancreatic Cancer (ASCEND) -A Single-Arm Phase Ib/II Trial
- Sponsor: Shandong Cancer Hospital and Institute
- Enrolled: 37

## Sources

- ClinicalTrials.gov NCT06844422: https://clinicaltrials.gov/study/NCT06844422

## Connected records

- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- drugs: [Ivonescimab](https://onco.cc/drugs/ivonescimab/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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