# Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial

Source: https://onco.cc/trials/nct06850090/  
OnCo record `nct06850090` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of trifluridine/tipiracil and capecitabine in colorectal cancer, run by Shandong Cancer Hospital and Institute, now recruiting.

## Summary

Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial is a phase 3, randomised interventional study registered as NCT06850090 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 210 participants, started 2025-07-30 and due to reach its primary completion in 2027-06. Interventions recorded: TAS-102; Capecitabine. Conditions listed: Rectal Cancer; Rectal Cancer Patients. Primary outcome: Complete response (CR) rate. Colorectal eligibility wording from the registry: "Histologically confirmed rectal adenocarcinoma with the following conditions:". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06850090
- Phase: 3
- Setting: Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial
- Sponsor: Shandong Cancer Hospital and Institute
- Enrolled: 210

## Sources

- ClinicalTrials.gov NCT06850090: https://clinicaltrials.gov/study/NCT06850090

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [Trifluridine/tipiracil](https://onco.cc/drugs/trifluridine-tipiracil/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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