# A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

Source: https://onco.cc/trials/nct06852222/  
OnCo record `nct06852222` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing Bleximenib in acute myeloid leukaemia, now recruiting.

## Summary

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukaemia (AML) is a phase 3 interventional study registered as NCT06852222, led by Janssen Research & Development, and recruiting on the registry. Official title: A Phase 3 Randomised, Double-Blind, Placebo-Controlled, Study of Bleximenib, Venetoclax and Azacitidine for the Treatment of Participants With Newly Diagnosed Acute Myeloid Leukaemia Harboring KMT2A Rearrangements or NPM1 Mutations Who Are Ineligible for Intensive Chemotherapy. Planned enrolment is 600 participants (estimated). The study started in 2025-06-04 and primary completion is expected in 2029-06-22. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Also known as: cAMeLot-2
- Tags: ctgov-ingest
- Registry id: NCT06852222
- Phase: 3
- Setting: A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Study of Bleximenib, Venetoclax and Azacitidine for the Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia Harboring KMT2A Rearrangements or NPM1 Mutations Who Are Ineligible for Intensive Chemotherapy
- Sponsor: Janssen Research & Development
- Enrolled: 600

## Sources

- ClinicalTrials.gov NCT06852222: https://clinicaltrials.gov/study/NCT06852222

## Connected records

- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Acute myeloid leukaemia in older or unfit patients](https://onco.cc/cancers/aml-older-unfit/), [NPM1-mutated and KMT2A-rearranged acute myeloid leukaemia](https://onco.cc/cancers/aml-npm1-kmt2a/)
- drugs: [Bleximenib](https://onco.cc/drugs/bleximenib/)
- companies: [Johnson & Johnson](https://onco.cc/companies/johnson-johnson/)

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