# An Open-label, Single-arm, Multicenter Phase II Study to Evaluate the Efficacy of Amivantamab in Combination With FOLFIRI as a Second-line Treatment in Patients

Source: https://onco.cc/trials/nct06855849/  
OnCo record `nct06855849` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Yonsei University, not yet recruiting.

## Summary

An Open-label, Single-arm, Multicenter Phase II Study to Evaluate the Efficacy of Amivantamab in Combination With FOLFIRI as a Second-line Treatment in Patients With RAS/BRAF Wild-type Advanced Colorectal Cancer Progressing on Prior Anti-EGFR Based Treatment. is a phase 2, interventional study registered as NCT06855849 by Yonsei University, with a registry enrolment figure of 85 participants, started 2025-05 and due to reach its primary completion in 2027-05. Interventions recorded: Amivantamab + FOLFIRI. Conditions listed: RAS/BRAF Wild-type Advanced Colorectal Cancer Patients. Primary outcome: Overall Response Rate. Colorectal eligibility wording from the registry: "The participant must have been previously diagnosed with histologically or cytologically confirmed unresectable or metastatic adenocarcinoma of the colon or rectum". Sites: South Korea. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06855849
- Phase: 2
- Setting: An Open-label, Single-arm, Multicenter Phase II Study to Evaluate the Efficacy of Amivantamab in Combination With FOLFIRI as a Second-line Treatment in Patients With RAS/BRAF Wild-type Advanced Colorectal Cancer Progressing on Prior Anti-EGFR Based Treatment.
- Sponsor: Yonsei University
- Enrolled: 85

## Sources

- ClinicalTrials.gov NCT06855849: https://clinicaltrials.gov/study/NCT06855849

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06855849.json