# Second-line Standard Treatment Sequential TAS-102 and Bevacizumab Combined With Local Treatment in Advanced Colorectal Cancer

Source: https://onco.cc/trials/nct06856187/  
OnCo record `nct06856187` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of trifluridine/tipiracil and bevacizumab (glioblastoma use) in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Second-line Standard Treatment Sequential TAS-102 and Bevacizumab Combined With Local Treatment in Advanced Colorectal Cancer is a phase 2, randomised interventional study registered as NCT06856187 by Fudan University, with a registry enrolment figure of 119 participants, started 2025-02-28 and due to reach its primary completion in 2026-06-30. Interventions recorded: TAS-102+bevacizumab+local treatment; Standard chemotherapy. Conditions listed: Metastatic Colorectal Cancer (CRC). Primary outcome: Time to treatment failure (TTF). Colorectal eligibility wording from the registry: "* Unresectable colorectal adenocarcinoma confirmed by histopathology or cytology;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: TASBEL
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06856187
- Phase: 2
- Setting: A Randomized, Phase II Clinical Study of Second-line Standard Treatment Sequential TAS-102 and Bevacizumab Combined With Local Treatment in Advanced Colorectal Cancer
- Sponsor: Fudan University
- Enrolled: 119

## Sources

- ClinicalTrials.gov NCT06856187: https://clinicaltrials.gov/study/NCT06856187

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [Trifluridine/tipiracil](https://onco.cc/drugs/trifluridine-tipiracil/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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