# Induction Treatment for Initially Unresectable Colorectal Liver Metastases: Combined Hepatic Arterial Infusion Pump Therapy With Systemic Therapy

Source: https://onco.cc/trials/nct06857773/  
OnCo record `nct06857773` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by The Netherlands Cancer Institute, now recruiting.

## Summary

Induction Treatment for Initially Unresectable Colorectal Liver Metastases: Combined Hepatic Arterial Infusion Pump Therapy With Systemic Therapy is a phase 3, randomised interventional study registered as NCT06857773 by The Netherlands Cancer Institute, with a registry enrolment figure of 306 participants, started 2024-11-21 and due to reach its primary completion in 2030-01. Interventions recorded: Intra arterial infusion Floxuridine (FUDR) combined with systemic therapy; Hepatic arterial infusion pump (HAIP); Systemic therapy (standard of care). Conditions listed: Colorectal Neoplasms; Floxuridine; Liver Metastases; Vascular Access Device. Primary outcome: Overall survival. Colorectal eligibility wording from the registry: "* Histologically confirmed colorectal adenocarcinoma". Sites: Netherlands. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: PUMP-IT RCT
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06857773
- Phase: 3
- Setting: Hepatic Arterial Infusion PUMP Chemotherapy Combined With Systemic Therapy Versus Systemic Therapy Alone as Induction Therapy for Initially Unresectable Colorectal Liver Metastases: a Randomised Controlled Trial
- Sponsor: The Netherlands Cancer Institute
- Enrolled: 306

## Sources

- ClinicalTrials.gov NCT06857773: https://clinicaltrials.gov/study/NCT06857773

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06857773.json