# Thoracic Radiotherapy and Inhibition of PD-1 and LAG-3 for Locally Advanced Non-Small Cell Lung Cancer

Source: https://onco.cc/trials/nct06865339/  
OnCo record `nct06865339` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cemiplimab and fianlimab in lung cancer, run by Montefiore Medical Center, now recruiting.

## Summary

Thoracic Radiotherapy and Inhibition of PD-1 and LAG-3 for Locally Advanced Non-Small Cell Lung Cancer is a phase 2, interventional study registered as NCT06865339 by Montefiore Medical Center, with a registry enrolment figure of 76 participants, started 2025-08-07 and due to reach its primary completion in 2027-08. Interventions recorded: Cemiplimab; Fianlimab; Radiotherapy; Platinum Doublet Chemotherapy (PDC). Conditions listed: NSCLC; Locally Advanced. Primary outcome: Objective Response Rate (ORR) to induction IO therapy. Lung eligibility wording from the registry: "* Previously untreated and biopsy-proven NSCLC, with measurable disease (at least 1 unidimensional, radiographically measurable lesion based on RECIST v1". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: TRIPL
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06865339
- Phase: 2
- Setting: TRIPL: Thoracic Radiotherapy and Inhibition of PD-1 and LAG-3 for Locally Advanced Non-Small Cell Lung Cancer
- Sponsor: Montefiore Medical Center
- Enrolled: 76

## Sources

- ClinicalTrials.gov NCT06865339: https://clinicaltrials.gov/study/NCT06865339

## Connected records

- cancers: [Unresectable stage III non-small-cell lung cancer](https://onco.cc/cancers/stage-iii-unresectable-nsclc/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Cemiplimab](https://onco.cc/drugs/cemiplimab/), [Fianlimab](https://onco.cc/drugs/fianlimab/)
- companies: [Regeneron](https://onco.cc/companies/regeneron/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06865339.json