# Study of MCLA-129 in the Treatment of Advanced Non-small Cell Lung Cancer with AGA and MET Amplification.

Source: https://onco.cc/trials/nct06885840/  
OnCo record `nct06885840` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of MCLA-129 in lung cancer, run by Betta Pharmaceuticals Co., Ltd., not yet recruiting.

## Summary

Study of MCLA-129 in the Treatment of Advanced Non-small Cell Lung Cancer with AGA and MET Amplification. is a phase 2, interventional study registered as NCT06885840 by Betta Pharmaceuticals Co., Ltd., with a registry enrolment figure of 100 participants, started 2025-03-31 and due to reach its primary completion in 2028-04. Interventions recorded: MCLA-129. Conditions listed: Non-Small Cell Lung Cancer. Primary outcome: Overall Response Rate (ORR). Lung eligibility wording from the registry: "* Subjects must have histologically or cytologically confirmed locally advanced unresectable or metastatic NSCLC". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06885840
- Phase: 2
- Setting: A Multi-cohort, Open-label Phase II Study to Evaluate the Efficacy and Safety of the Anti-EGFR/c-Met Bispecific Antibody MCLA-129 in Patients with Advanced Non-Small Cell Lung Cancer with Actionable Gene Alterations and MET Amplification.
- Sponsor: Betta Pharmaceuticals Co., Ltd.
- Enrolled: 100

## Sources

- ClinicalTrials.gov NCT06885840: https://clinicaltrials.gov/study/NCT06885840

## Connected records

- cancers: [EGFR-mutated non-small-cell lung cancer](https://onco.cc/cancers/egfr-mutant-nsclc/), [MET exon 14 and MET-amplified non-small-cell lung cancer](https://onco.cc/cancers/met-altered-nsclc/)
- drugs: [MCLA-129](https://onco.cc/drugs/mcla-129/)
- companies: [Betta Pharmaceuticals](https://onco.cc/companies/betta/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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