# Personalized Tumor Neoantigen MRNA Therapy for Advanced Pancreatic Cancer.

Source: https://onco.cc/trials/nct06888648/  
OnCo record `nct06888648` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of sintilimab in pancreatic cancer, run by Zhejiang University, not yet recruiting.

## Summary

Personalized Tumor Neoantigen MRNA Therapy for Advanced Pancreatic Cancer. is a phase 1/2, interventional study registered as NCT06888648 by Zhejiang University, with a registry enrolment figure of 30 participants, started 2025-04-01 and due to reach its primary completion in 2027-04-01. Interventions recorded: individualized anti-tumor new antigen iNeo-Vac-R01 injection; mFOLFIRINOX Treatment Regimen; Sintilimab injection. Conditions listed: Pancreatic Cancer Metastatic; Pancreatic Cancer Non-resectable. Primary outcome: Occurence and frequence of AE and SAE. Pancreatic eligibility wording from the registry: "Evaluation as metastatic pancreatic cancer or postoperative recurrence according to the 2024 NCCN guidelines;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06888648
- Phase: 1/2
- Setting: Clinical Study to Evaluate the Safety and Efficacy of Personalized Tumor Neoantigen MRNA Therapy in Combination with PD-1 Antibody and Chemotherapy for Advanced Pancreatic Cancer.
- Sponsor: Zhejiang University
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT06888648: https://clinicaltrials.gov/study/NCT06888648

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Sintilimab](https://onco.cc/drugs/sintilimab/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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