# mFOLFOXIRI Plus PD-1 Inhibitor vs mFOLFOX6 as Neoadjuvant Therapy for Locally Advanced Colon Cancer

Source: https://onco.cc/trials/nct06890624/  
OnCo record `nct06890624` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Sun Yat-sen University, not yet recruiting.

## Summary

mFOLFOXIRI Plus PD-1 Inhibitor vs mFOLFOX6 as Neoadjuvant Therapy for Locally Advanced Colon Cancer is a phase 2, randomised interventional study registered as NCT06890624 by Sun Yat-sen University, with a registry enrolment figure of 138 participants, started 2026-10-01 and due to reach its primary completion in 2029-10-01. Interventions recorded: cmFOLFOXIRI plus PD-1 inhibitor; mFOLFOX6. Conditions listed: Colon Cancer (Stage II &Amp;Amp; III). Primary outcome: Pathologic complete response rate. Colorectal eligibility wording from the registry: "Histological or cytological documentation of adenocarcinoma of the colon (≥ 12 cm from the anal verge)". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: OPTICAL-3
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06890624
- Phase: 2
- Setting: Chinese Modified FOLFOXIRI Combined With PD-1 Inhibitor Versus mFOLFOX6 as Neoadjuvant Therapy for Locally Advanced Colon Cancer (cT4/N2): A Multicenter, Randomized, Controlled, Phase II Trial
- Sponsor: Sun Yat-sen University
- Enrolled: 138

## Sources

- ClinicalTrials.gov NCT06890624: https://clinicaltrials.gov/study/NCT06890624

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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