# Pre-Operative Treatment in REseCTable COlon CanceR

Source: https://onco.cc/trials/nct06899477/  
OnCo record `nct06899477` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of FOLFOXIRI, fOLFOX (5-FU, leucovorin, oxaliplatin) and cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Dominik Paul Modest, not yet recruiting.

## Summary

Pre-Operative Treatment in REseCTable COlon CanceR is a phase 3, randomised interventional study registered as NCT06899477 by Dominik Paul Modest, with a registry enrolment figure of 714 participants, started 2025-04 and due to reach its primary completion in 2033-04. Interventions recorded: mFOLFOXIRI; mFOLFOX-6; CAPOX. Conditions listed: Colo-rectal Cancer; Colon Cancer; Colon Carcinoma. Primary outcome: Disease-free survival (DFS). Colorectal eligibility wording from the registry: "Histologically confirmed adenocarcinoma of the colon or upper rectum". Sites: Germany. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06899477
- Phase: 3
- Setting: Pre-Operative Treatment in REseCTable COlon CanceR (PROTECTOR/FIRE-10; AIO-KRK-0620; IAG-VO-0323) Prospective, Randomized, Open, Multicenter Phase III Trial to Investigate the Efficacy Preoperative Systemic Therapy in Advanced Colon Cancer
- Sponsor: Dominik Paul Modest
- Enrolled: 714

## Sources

- ClinicalTrials.gov NCT06899477: https://clinicaltrials.gov/study/NCT06899477

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan)](https://onco.cc/drugs/folfoxiri/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06899477.json