# Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer

Source: https://onco.cc/trials/nct06903858/  
OnCo record `nct06903858` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of toripalimab and celecoxib in colorectal cancer, run by Sun Yat-sen University, now recruiting.

## Summary

Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer is a phase 2, interventional study registered as NCT06903858 by Sun Yat-sen University, with a registry enrolment figure of 105 participants, started 2025-06-01 and due to reach its primary completion in 2028-04-01. Interventions recorded: Toripalimab plus celecoxib; Non-operative management; Curative-intent surgery. Conditions listed: Colorectal Cancer; Microsatellite Instability High; Mismatch Repair Deficiency. Primary outcome: Event-free survival (EFS). Colorectal eligibility wording from the registry: "Histologically confirmed colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: PICC-3
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06903858
- Phase: 2
- Setting: Toripalimab Plus Celecoxib With Response-adapted Non-operative Management for Mismatch Repair-deficient or Microsatellite Instability-high Locally Advanced Colorectal Cancer (PICC-3): a Multicenter, Single-arm, Phase 2 Trial
- Sponsor: Sun Yat-sen University
- Enrolled: 105

## Sources

- ClinicalTrials.gov NCT06903858: https://clinicaltrials.gov/study/NCT06903858

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Celecoxib](https://onco.cc/drugs/celecoxib/), [Toripalimab](https://onco.cc/drugs/toripalimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06903858.json