# ONT01 and Gemcitabine/Nab-paclitaxel as Second Line Therapy for Metastatic Pancreatic Ductal Adenocarcinoma

Source: https://onco.cc/trials/nct06904378/  
OnCo record `nct06904378` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of gemcitabine and nab-paclitaxel in pancreatic cancer, run by Washington University School of Medicine, now recruiting.

## Summary

ONT01 and Gemcitabine/Nab-paclitaxel as Second Line Therapy for Metastatic Pancreatic Ductal Adenocarcinoma is a phase 1/2, randomised interventional study registered as NCT06904378 by Washington University School of Medicine, with a registry enrolment figure of 61 participants, started 2026-03-25 and due to reach its primary completion in 2028-09-30. Interventions recorded: ONT01; Gemcitabine; Nab paclitaxel. Conditions listed: Metastatic Pancreatic Ductal Adenocarcinoma. Primary outcome: Recommended phase II dose (RP2D) (Phase I only); Number of participants with dose-limiting toxicities (DLTs) (Phase I only); Progression-free rate at 6 months (RP2D participants in Phase I and Phase II participants only). Pancreatic eligibility wording from the registry: "* Histologically or cytologically confirmed adenocarcinoma of the pancreas". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06904378
- Phase: 1/2
- Setting: Phase I/II Clinical Trial of ONT01 and Gemcitabine/Nab-paclitaxel as Second Line Therapy for Metastatic Pancreatic Ductal Adenocarcinoma: Reprogramming Tumor-associated Myeloid Cells
- Sponsor: Washington University School of Medicine
- Enrolled: 61

## Sources

- ClinicalTrials.gov NCT06904378: https://clinicaltrials.gov/study/NCT06904378

## Connected records

- cancers: [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Gemcitabine](https://onco.cc/drugs/gemcitabine/), [Nab-paclitaxel](https://onco.cc/drugs/nab-paclitaxel/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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