# Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)

Source: https://onco.cc/trials/nct06907342/  
OnCo record `nct06907342` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by St. Olavs Hospital, now recruiting.

## Summary

Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1) is a phase 2, interventional study registered as NCT06907342 by St. Olavs Hospital, with a registry enrolment figure of 148 participants, started 2025-05-23 and due to reach its primary completion in 2027-12. Interventions recorded: FOLFOX or FOLFIRI. Conditions listed: Tumor, Colorectal; Organoids; Tumoroid; Metastatic Colorectal Cancer; Core Needle Biopsy; First-line Treatment. Primary outcome: Test the feasibility of using a functional precision medicine platform to select oxaliplatin-based versus irinotecan-based chemotherapy regimens for patients with metastatic colorectal cancer.; Test the feasibility of using a functional precision medicine platform to select oxaliplatin-based versus . Colorectal eligibility wording from the registry: "Histologically confirmed pMMR/MSS adenocarcinoma originating from the colon or rectum". Sites: Norway. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: COSENSE-1
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06907342
- Phase: 2
- Setting: COSENSE-1: A Feasibility Study for Using a Functional Precision Medicine Platform to Select Oxaliplatin-based Versus Irinotecan-based Chemotherapy Regimens for Patients With Metastatic Colorectal Cancer
- Sponsor: St. Olavs Hospital
- Enrolled: 148

## Sources

- ClinicalTrials.gov NCT06907342: https://clinicaltrials.gov/study/NCT06907342

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06907342.json