# Paclitaxel Polymeric Micelles and Carboplatin in Combination With Iparomilimab and Tuvonralimab Neoadjuvant Therapy for Triple-negative Breast Cancer（UPGRADE-TN

Source: https://onco.cc/trials/nct06910072/  
OnCo record `nct06910072` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial of carboplatin in triple-negative breast cancer, run by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, now recruiting.

## Summary

Paclitaxel Polymeric Micelles and Carboplatin in Combination With Iparomilimab and Tuvonralimab Neoadjuvant Therapy for Triple-negative Breast Cancer（UPGRADE-TNBC） is a phase 2/3, interventional study registered as NCT06910072 by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, with a registry enrolment figure of 32 participants, started 2025-07-21 and due to reach its primary completion in 2027-06-01. Interventions recorded: paclitaxel polymeric micelles + carboplatin + iparomilimab and tuvonralimab. Conditions listed: Triple-Negative Breast Cancer (TNBC); Neoadjuvant Therapy. Triple-negative eligibility wording from the registry: "* Triple-negative breast cancer". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: UPGRADE-TNBC
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT06910072
- Phase: 2/3
- Setting: Paclitaxel Polymeric Micelles and Carboplatin in Combination With Iparomilimab and Tuvonralimab Neoadjuvant Therapy for Triple-negative Breast Cancer（UPGRADE-TNBC）
- Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Enrolled: 32

## Sources

- ClinicalTrials.gov NCT06910072: https://clinicaltrials.gov/study/NCT06910072

## Connected records

- cancers: [Early triple-negative breast cancer](https://onco.cc/cancers/tnbc-early/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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