# A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct06919510/  
OnCo record `nct06919510` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Sun Yat-sen University, not yet recruiting.

## Summary

A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT06919510 by Sun Yat-sen University, with a registry enrolment figure of 90 participants, started 2025-04-01 and due to reach its primary completion in 2026-06-01. Interventions recorded: lvonescimab; CAPOX (oxaliplatin/capecitabine); radiotherapy; Surgery or watch&wait. Conditions listed: Rectal Adenocarcinoma. Primary outcome: Adverse events; Complete response rate; Clinical complete response rate. Colorectal eligibility wording from the registry: "Histologically proven rectal adenocarcinoma;". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06919510
- Phase: 2
- Setting: A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Lvonescimab and Chemotherapy Versus Neoadjuvant Short-course Radiotherapy Followed by Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer
- Sponsor: Sun Yat-sen University
- Enrolled: 90

## Sources

- ClinicalTrials.gov NCT06919510: https://clinicaltrials.gov/study/NCT06919510

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/)
- companies: [Akeso](https://onco.cc/companies/akeso/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06919510.json