# Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

Source: https://onco.cc/trials/nct06922591/  
OnCo record `nct06922591` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of TNG462, Zoldonrasib, Daraxonrasib in pancreatic ductal adenocarcinoma, run by Tango Therapeutics, Inc., now recruiting.

## Summary

Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients is a phase 1/2 interventional study registered as NCT06922591 by Tango Therapeutics, Inc., with 183 participants planned, started 2025-05-31 and due to reach its primary completion in 2027-06. Interventions recorded: TNG462, RMC-9805, RMC-6236, mFOLFIRINOX, gemcitabine/nab-paclitaxel. Conditions listed: PDAC, PDAC - Pancreatic Ductal Adenocarcinoma, NSCLC, RAS Mutation. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT06922591
- Phase: 1/2
- Setting: A Phase 1/2, Multicenter, Open-Label Study to Evaluate Safety, Tolerability & Antitumor Activity of TNG462 in Combination With Other Agents in Patients With Pancreatic Cancer With MTAP Loss and Pancreatic or Non-Small Cell Lung Cancer With MTAP Loss & RAS Mutation
- Sponsor: Tango Therapeutics, Inc.
- Enrolled: 183

## Sources

- ClinicalTrials.gov NCT06922591: https://clinicaltrials.gov/study/NCT06922591

## Connected records

- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- drugs: [Daraxonrasib](https://onco.cc/drugs/daraxonrasib/), [FOLFIRINOX / mFOLFIRINOX](https://onco.cc/drugs/folfirinox/), [Gemcitabine](https://onco.cc/drugs/gemcitabine/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/), [TNG462](https://onco.cc/drugs/tng462/), [Zoldonrasib](https://onco.cc/drugs/zoldonrasib/)
- companies: [Tango Therapeutics](https://onco.cc/companies/tango-therapeutics/)

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