# The Aim of This Study is to Assess the Efficacy and Safety of Chidamide, Regorafenib in Combination With Iparomlimab and Tuvonralimab for the Treatment of Advan

Source: https://onco.cc/trials/nct06930118/  
OnCo record `nct06930118` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Shanghai Changzheng Hospital, now recruiting.

## Summary

The Aim of This Study is to Assess the Efficacy and Safety of Chidamide, Regorafenib in Combination With Iparomlimab and Tuvonralimab for the Treatment of Advanced Colorectal Cancer in Third-line Therapy and Subsequent Lines. is a phase 2, interventional study registered as NCT06930118 by Shanghai Changzheng Hospital, with a registry enrolment figure of 60 participants, started 2025-04-10 and due to reach its primary completion in 2027-04-30. Interventions recorded: chidamide, regorafenib, and iparomlimab/tuvonralimab. Conditions listed: Advanced Colorectal Cancer in the Third-line Treatment and Beyond; pMMR/MSS Advanced Colorectal Cancer. Primary outcome: Objective response rate, ORR. Colorectal eligibility wording from the registry: "* Patients with advanced colorectal adenocarcinoma confirmed by histology or cytology;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06930118
- Phase: 2
- Setting: An Exploratory Study Investigating the Combination of Chidamide, Regorafenib, Plus Iparomlimab and Tuvonralimab for the Treatment of Drug-esistant and Efractory Dvanced Colorectal Cancer
- Sponsor: Shanghai Changzheng Hospital
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT06930118: https://clinicaltrials.gov/study/NCT06930118

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06930118.json