# SENECA: First Line metaStatic pancrEatic caNcer Primary and Distant (if Oligometastatic) lEsion direCted rAdiotherapy

Source: https://onco.cc/trials/nct06946420/  
OnCo record `nct06946420` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in pancreatic cancer, run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS, active but no longer recruiting.

## Summary

SENECA: First Line metaStatic pancrEatic caNcer Primary and Distant (if Oligometastatic) lEsion direCted rAdiotherapy is a phase 3, randomised interventional study registered as NCT06946420 by Fondazione Policlinico Universitario Agostino Gemelli IRCCS, with a registry enrolment figure of 108 participants, started 2025-01-10 and due to reach its primary completion in 2030-01-10. Interventions recorded: SBRT or RT on primary pancreatic and/or metastatic distant lesions before chemotherapy; Standard systemic therapy (chemotherapy) without RT/SBRT. Conditions listed: Radiation Therapy; SBRT; Pancreatic Cancer Metastatic. Primary outcome: Absence of symtomps. Pancreatic eligibility wording from the registry: "* Patients diagnosed with pancreatic cancer, metastatic, candidate for first-line treatment standard systemic; either newly diagnosed in metastatic stage or first progression to metastasis". Sites: Italy. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: SENECA
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06946420
- Phase: 3
- Setting: SENECA: First Line metaStatic pancrEatic caNcer Primary and Distant (if Oligometastatic) lEsion direCted rAdiotherapy, a Phase III Randomized Multicentric Trial
- Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Enrolled: 108

## Sources

- ClinicalTrials.gov NCT06946420: https://clinicaltrials.gov/study/NCT06946420

## Connected records

- cancers: [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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