# Radiotherapy + Systemic Therapy as Conversion Therapy for pMMR/MSS T4M0 Colon Cancer（Neo-Color）

Source: https://onco.cc/trials/nct06949111/  
OnCo record `nct06949111` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cAPOX (capecitabine, oxaliplatin) and capecitabine in colorectal cancer, run by Hebei Medical University Fourth Hospital, now recruiting.

## Summary

Radiotherapy + Systemic Therapy as Conversion Therapy for pMMR/MSS T4M0 Colon Cancer（Neo-Color） is a phase 2, randomised interventional study registered as NCT06949111 by Hebei Medical University Fourth Hospital, with a registry enrolment figure of 128 participants, started 2025-05-15 and due to reach its primary completion in 2028-05-30. Interventions recorded: radiotherapy; CAPOX; Capecitabine; Iparomlimab and Tuvonralimab Injection. Conditions listed: Colon Cancer. Primary outcome: Tumor Complete Response (CR) Rate. Colorectal eligibility wording from the registry: "Histopathologically confirmed diagnosis of colon adenocarcinoma (including mucinous adenocarcinoma), identified as pMMR/MSS type; the primary tumor site must be specified (left colon defined as from the splenic flexure to the rectosigmoid junction, right colon defined as from the cecum to the proxim". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06949111
- Phase: 2
- Setting: Efficacy and Safety of Conversion Therapy for pMMR/MSS T4M0 Colon Cancer Patients Treated With Radiotherapy and Systemic Therapy: a Prospective, Open-label, Multi-center, Randomized Controlled Trial（Neo-Color）
- Sponsor: Hebei Medical University Fourth Hospital
- Enrolled: 128

## Sources

- ClinicalTrials.gov NCT06949111: https://clinicaltrials.gov/study/NCT06949111

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06949111.json