# Efficacy And Safety Of Hydroxychloroquine Combined With Methotrexate, Capecitabine And Bevacizumab Vs. Regorafenib In Participants With Refractory Metastatic Co

Source: https://onco.cc/trials/nct06949982/  
OnCo record `nct06949982` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of regorafenib in colorectal cancer, run by Sergey Orlov, MD, now recruiting.

## Summary

Efficacy And Safety Of Hydroxychloroquine Combined With Methotrexate, Capecitabine And Bevacizumab Vs. Regorafenib In Participants With Refractory Metastatic Colorectal Cancer With Mutations In RAS Genes is a phase 2, randomised interventional study registered as NCT06949982 by Sergey Orlov, MD, with a registry enrolment figure of 60 participants, started 2025-03-17 and due to reach its primary completion in 2027-04. Interventions recorded: experimental group x-MAP; Regorafenib (BAY 73-4506). Conditions listed: Metastatic Colorectal Cancer (mCRC); Colorectal Neoplasms. Primary outcome: Objective Response Rate (ORR) Per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1); Progression-free Survival (PFS) Per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1). Colorectal eligibility wording from the registry: "* Histologically confirmed diagnosis of colorectal cancer (CRC) with distant metastases". Sites: Russia. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: x-МАР
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06949982
- Phase: 2
- Setting: A Randomized Trial To Compare Efficacy And Safety Of Hydroxychloroquine Combined With Methotrexate, Capecitabine And Bevacizumab Versus Regorafenib In Participants With Refractory Metastatic Colorectal Cancer With Mutations In RAS Genes
- Sponsor: Sergey Orlov, MD
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT06949982: https://clinicaltrials.gov/study/NCT06949982

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Anti-angiogenic therapy](https://onco.cc/technologies/antiangiogenic/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Regorafenib](https://onco.cc/drugs/regorafenib/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct06949982.json