# Node-Sparing Short-Course Radiotherapy Plus Chemotherapy, Bevacizumab and PD-1 Inhibitor in Metastatic pMMR/MSS Colorectal Cancer (MODIFI-CRC)

Source: https://onco.cc/trials/nct06958419/  
OnCo record `nct06958419` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.

## Summary

Node-Sparing Short-Course Radiotherapy Plus Chemotherapy, Bevacizumab and PD-1 Inhibitor in Metastatic pMMR/MSS Colorectal Cancer (MODIFI-CRC) is a phase 2/3, randomised interventional study registered as NCT06958419 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 286 participants, started 2025-05-01 and due to reach its primary completion in 2030-12-31. Interventions recorded: Node-Sparing Radiotherapy plus first-line therapy; First-line treatment. Conditions listed: Immune Checkpoint Therapy; Radiotherapy; Metastatic Colorectal Cancer (CRC). Primary outcome: Objective Response Rate(ORR); Progression-free survival (PFS). Colorectal eligibility wording from the registry: "* Histologically or cytologically confirmed colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06958419
- Phase: 2/3
- Setting: Node-Sparing Short-Course Radiotherapy Followed by First-Line Chemotherapy Plus Bevacizumab and PD-1 Inhibitor Versus Chemotherapy Plus Bevacizumab Alone in Metastatic pMMR/MSS Colorectal Cancer: A Randomized, Phase II/III Trial (MODIFI-CRC)
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 286

## Sources

- ClinicalTrials.gov NCT06958419: https://clinicaltrials.gov/study/NCT06958419

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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