# Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct06959550/  
OnCo record `nct06959550` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of ivonescimab in colorectal cancer, run by M.D. Anderson Cancer Center, now recruiting.

## Summary

Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT06959550 by M.D. Anderson Cancer Center, with a registry enrolment figure of 90 participants, started 2025-07-28 and due to reach its primary completion in 2028-07-01. Interventions recorded: Ivonescimab. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: 1. Safety and Adverse Events (AEs). Colorectal eligibility wording from the registry: "Histological or cytological confirmed advanced, metastatic adenocarcinoma of colon or rectum". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06959550
- Phase: 2
- Setting: Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer
- Sponsor: M.D. Anderson Cancer Center
- Enrolled: 90

## Sources

- ClinicalTrials.gov NCT06959550: https://clinicaltrials.gov/study/NCT06959550

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Ivonescimab](https://onco.cc/drugs/ivonescimab/)
- companies: [Summit Therapeutics](https://onco.cc/companies/summit-therapeutics/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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