# A Clinical Study to Evaluate the Efficacy and Safety of Envafolimab Combined With Cetuxima-βand mFOLFOX6 in Patients With MSS, RAS/BRAF Wild-Type Metastatic Col

Source: https://onco.cc/trials/nct06959693/  
OnCo record `nct06959693` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial of envafolimab and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Sun Yat-sen University, not yet recruiting.

## Summary

A Clinical Study to Evaluate the Efficacy and Safety of Envafolimab Combined With Cetuxima-βand mFOLFOX6 in Patients With MSS, RAS/BRAF Wild-Type Metastatic Colorectal Cancer (mCRC) is a phase 2/3, randomised interventional study registered as NCT06959693 by Sun Yat-sen University, with a registry enrolment figure of 590 participants, started 2025-06-01 and due to reach its primary completion in 2028-09-30. Interventions recorded: Cetuxima-β; Envafolimab; mFOLFOX6. Conditions listed: Metastatic Colorectal Cancer (CRC). Primary outcome: Progressin Free Survival，PFS. Colorectal eligibility wording from the registry: "Histopathologically confirmed untreated advanced colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06959693
- Phase: 2/3
- Setting: mFOLFOX and Cetuximab - β With or Without Envafolimab for MSS, RAS/BRAF Wild - Type Advanced Unresectable CRC: Prospective, Randomized, Controlled Phase II/III Trial
- Sponsor: Sun Yat-sen University
- Enrolled: 590

## Sources

- ClinicalTrials.gov NCT06959693: https://clinicaltrials.gov/study/NCT06959693

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Envafolimab](https://onco.cc/drugs/envafolimab/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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