# A Prospective Multicenter Study: Ivosimab + Chemotherapy as Neoadjuvant for Resectable pMMR/MSS CRC Liver Mets

Source: https://onco.cc/trials/nct06972498/  
OnCo record `nct06972498` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by The Fourth Affiliated Hospital of Zhejiang University School of Medicine, not yet recruiting.

## Summary

A Prospective Multicenter Study: Ivosimab + Chemotherapy as Neoadjuvant for Resectable pMMR/MSS CRC Liver Mets is a phase 2, interventional study registered as NCT06972498 by The Fourth Affiliated Hospital of Zhejiang University School of Medicine, with a registry enrolment figure of 35 participants, started 2025-07-01 and due to reach its primary completion in 2027-12-30. Interventions recorded: Patients will receive ivosimab combined with the XELOX/FOLFOX regimen, followed by radical surgery 4-6 weeks after the last dose; adjuvant chemotherapy will continue for 3 months postoperatively.. Conditions listed: Colorectal Cancer With Liver Metastasis. Primary outcome: ORR. Colorectal eligibility wording from the registry: "Patients with pathologically or cytologically confirmed colorectal adenocarcinoma liver metastasis, and immunohistochemistry or genetic testing confirms pMMR/MSS". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06972498
- Phase: 2
- Setting: A Prospective, Single-Arm, Multicenter Clinical Study on the Efficacy and Safety of Ivosimab Combined With Chemotherapy as Neoadjuvant Therapy in Patients With Resectable pMMR/MSS Colorectal Cancer Liver Metastases
- Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine
- Enrolled: 35

## Sources

- ClinicalTrials.gov NCT06972498: https://clinicaltrials.gov/study/NCT06972498

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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