# Glumetinib Combined With Fruquintinib in the Treatment of MET Amplification or Protein Overexpression in Third-Line Unresectable Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct06980532/  
OnCo record `nct06980532` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of fruquintinib in colorectal cancer, run by Liu Huang, now recruiting.

## Summary

Glumetinib Combined With Fruquintinib in the Treatment of MET Amplification or Protein Overexpression in Third-Line Unresectable Metastatic Colorectal Cancer is a phase 1/2, interventional study registered as NCT06980532 by Liu Huang, with a registry enrolment figure of 42 participants, started 2025-04-25 and due to reach its primary completion in 2028-12-30. Interventions recorded: Glumetinib Combined with Fruquintinib. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Recommended dose for Phase II; Objective response rate(ORR). Colorectal eligibility wording from the registry: "Patients with unresectable metastatic colorectal cancer with microsatellite stable (MSS) confirmed by pathology or histology;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06980532
- Phase: 1/2
- Setting: Glumetinib Combined With Fruquintinib in the Treatment of MET Amplification or Protein Overexpression in Third-Line Unresectable Metastatic Colorectal Cancer: A Prospective, Exploratory, Open-Label Clinical Study
- Sponsor: Liu Huang
- Enrolled: 42

## Sources

- ClinicalTrials.gov NCT06980532: https://clinicaltrials.gov/study/NCT06980532

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Anti-angiogenic therapy](https://onco.cc/technologies/antiangiogenic/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Fruquintinib](https://onco.cc/drugs/fruquintinib/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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